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Despite this complexity, numerous studies have reached conclusions on the intricate process of ASM remodeling, which includes ASM cell proliferation and apoptosis (255, 256), dysregulation Ca2+ homeostasis (257259), excessive production of ECM components like fibronectin and collagen type I that play a role in stimulating the proliferation of human ASM cells (260264), and factors associated with immune cells, airway cells, growth factors, cytokine and inflammatory mediators (263, 265268)

Relevant to brain tissue, perturbations (increases or decreases) in levels of several metabolites, including those associated with GSH (e.g., glycine), have been reported 25 h post mortem (Gonzalez-Riano et al., 2017)

Collagen contributes to the skin's structure and resistance