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Because collagen is not a complete protein (it lacks the essential amino acid tryptophan), it should not be your only protein source, but these higher doses can be helpful for heavy training phases

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Transcription factor Nrf2 has shown the ability, both in in vitro and in in vivo experiments, to activate a series of vitagenes including (Hsp) Hsp32, Hsp70, and thioredoxin, conferring protection against oxidative stress, and contributing to establish a cytoprotective state in inflammation and neurodegenerative disorders [135, 136]

Severe cramps, or those associated with heat exhaustion or dehydration may require blood tests to check electrolyte levels
Insulin-like growth factor (IGF) system in liver diseases
