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Active ADAM10 cleaves the extracellular domain of GPVI, triggers platelet secretion, and impairs the subsequent events of platelet activation, such as platelet aggregation and adhesion to fibrinogen and vWF (94, 95)

Public written comments can be submitted to docket FDA-2025-N-6895 through July 22, 2026

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Journal of Physiology, Paris, 97 (23), 221226
