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A recent study demonstrated that Lobetyolin disrupts Gln metabolism by downregulating SLC1A5 expression in MDA-MB-231 and MDA-MB-468 breast cancer cells, induces apoptosis in these cells and exerts anti-tumor effects (83)

[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Giri S.S., Kim M.J., Kim S.G., Kim S.W., Kang J.W., Kwon J., Lee S.B., Jung W.J., Sukumaran V., Park S.C

Circulation 112: 34513461, 2005 [DOI] [PMC free article] [PubMed] [Google Scholar] 61.Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold JA

failure of this regulation allows excessive IL-1 and IL-18 production, amplifying systemic inflammation, which is particularly relevant in SLE and RA

Hepatocyte injury triggered by ER stress, mitochondrial dysfunction, or xenobiotics produces ROS, mitochondrial DNA, and apoptotic bodies that activate Kupffer cells (KCs) and HSCs (HSCs)