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Excess iron could promote the Fenton reaction in PD lesions, that is, lead to the production of more ROS, which is unfavorable for the treatment of PD

Moreover, cosubstrate binding mechanisms are unique for the classical type of GPX1 but cannot operate in GPX3 and GPX4 (11) (Figure 3)
Moi et al, 1994)

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Facial skin collagen significantly increased after 16 weeks of treatment
