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Excess iron could promote the Fenton reaction in PD lesions, that is, lead to the production of more ROS, which is unfavorable for the treatment of PD

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Moreover, cosubstrate binding mechanisms are unique for the classical type of GPX1 but cannot operate in GPX3 and GPX4 (11) (Figure 3)

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Facial skin collagen significantly increased after 16 weeks of treatment

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