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In 2022, approximately 2.3 million new cases of breast cancer were reported, and 670,000 breast cancer-related death occurred globally [2]

However, in some organisms like fishes, metals can have a long biological half-life that may extend to more than a year in the liver and kidney, reflecting the poor efficiency of excretion pathways (Ruttkay-Nedecky et al., 2013)

Currently, ferroptosis inhibitors such as Ferrostatin-1 and Liproxstatin-1 have entered clinical trials, potentially leading to precision treatment strategies that integrate TfR1 detection techniques ( Despite the promising clinical prospects of TfR1 in OA, challenges remain in its practical application

As noted above, there are few reports of natural functions of ferroptosis

[ 4 ] Some small human studies reported improvements in sleep efficiency and sleep latency in chronic insomniacs, though the effects were described as weak and not consistently different from placebo