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Response to letter by Balta et al

Some individuals may experience the following side effects: Headaches Digestive issues (such as nausea or diarrhea) Dizziness Sleep disturbances (trouble sleeping or vivid dreams) Increased anxiety or restlessness in sensitive individuals Safety Concerns with Long-Term Use: Potential for dependence, which may reduce effectiveness over time Possible drug interactions, particularly with blood thinners, antidepressants, or medications for high blood pressure Risk of worsening pre-existing conditions, such as hypertension or diabetes To reduce potential side effects, consider the following: Consult a healthcare provider before starting any new supplements, especially if you have underlying health conditions or take prescription medications

Nonogaki, K., Nozue, K

Readers must make their own assessment of the information contained herein and consider such other factors as they may deem relevant to their individual circumstances

As more PEGylated therapeutic agents receive FDA approval, more attention has been given to site-specific PEGylation of discrete or monodispersed PEG chains