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References: NHS

Zonulin causes TJ disassembly and thus violates the intestinal barrier ( Polyphenolic compounds (secondary plant metabolites with a long list of beneficial properties for humans) are other food components that improve intestinal integrity

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Geudj R, Chappuy H, Titomanlio L, et al

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