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Van Vliet EF, Knol MJ, Schiffelers RM et al (2023) Levodopa-loaded nanoparticles for the treatment of Parkinsons disease

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Formulation & Skin-Delivery Considerations (No Dosing Guidance) Carriers: Liposomes and other vesicular systems may improve skin retention/penetration of hydrophilic peptides like GHK-Cu (PMC)

Interestingly, the free drug group (Pd1-Pd2-SA) showed moderate efficacy against DR-B16F10 melanoma, which is mainly attributed to the quick clearance of small molecules after injection, highlighting the advantage of the hydrogel as a depot to control the sustained release of encapsulated small-molecule drugs

Why it matters: For individuals with PCOS, insulin resistance, metabolic concerns or chronic inflammation, GLP-1 support may help create a healthier internal environment for conception