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Although it can penetrate the BBB, its oral bioavailability, tissue-specific distribution and half-life have not been fully elucidated, potentially necessitating structural optimization or improvements in delivery systems

Bupropion is available in IR (three times a day), sustained-release (twice a day), and ER (once a day) formulations

This amino acid substitution has been shown to confer a 5-fold resistance to the nonnucleoside RdRp palm-1 inhibitor (dasabuvir) in GT1b 64

doi: 10.3945/ajcn.113.068015