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E1 is a thiamin pyrophosphate (TPP)-dependent -ketoacid dehydrogenase, R -lipoic acid functions as a prosthetic group essential for E2 transacetylase activity, and E3 is a flavin adenine dinucleotide (FAD)-dependent dihydrolipoamide dehydrogenase ( Figure 4 )

Should such successes be extended to humans, this would not only provide the opportunity for a spectrum of studies to further our understanding of thyroid physiology, pathophysiology, and disease, but could also pave the way for regenerating the full hormonal profile of a normally functioning thyroid gland and thereby restoring euthyroidism in its entirety for those affected by this lifelong disease (270)

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doi: 10.1084/jem.20140857

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