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Non-motor symptoms in Parkinson's disease encompass a variety of functions, such as disturbances in sleep-wake cycle regulation, cognitive dysfunction (such as frontal executive dysfunction, memory retrieval problems, dementia, and hallucinations), mood and affect disorders, autonomic dysfunction (primarily orthostatic hypotension, urogenital dysfunction, constipation, and excessive sweating), sensory symptoms (especially reduced sense of smell), and pain

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Distinct roles of -arrestin 1 and -arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1)

Untargeted metabolomic analysis Metabolomic sequencing of serum was performed as described previously [24], and untargeted metabolomic analysis of the NC and PD groups was performed by LCMS/MS, which was performed on a quadrupole electrostatic field Orbitrap high-resolution mass spectrometer