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In fact, because the FIH study might be the only opportunity to obtain concentrationresponse data at supratherapeutic doses for QTc analysis, a negative signal from such studies with highquality ECG recording may obviate the need for a dedicated thorough QT prolongation study.53 When a new topical drug candidate is tested systematic collection of localized reactions should be used
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doi: 10.3389/fphar.2016.00389
If medication isnt effectively managing symptoms, surgery may become an option
