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But under high oxidative load (poor sleep, alcohol, inflammation), this system gets overwhelmed

Can Assoc Radiol J 75:658670 Toyota N, Naito A, Kakizawa H et al (2005) Radiofrequency ablation therapy combined with cementoplasty for painful bone metastases: initial experience

The reason is that GCN5L protein has a high homology to catalytic domains of KAT2A and other family members, but the first generation inhibitors have low specificity for GCN5L, and often interfere with the function of other acetyltransferases