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The leaves are light green and may occasionally have short hairs, with prominent and sharp parts along the midrib

Some patients benefit from weekly injections initially, tapering to monthly maintenance once levels normalize

In the past 5 years there has been a plethora of advancements, including the development of exciting tools and technology (Supplementary Box 4), to further advance our understanding of how NAD + levels influence or are influenced by complex signalling, metabolic and cellular pathways

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