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Suppressor of cytokine signaling-3 haploinsufficiency in mice enhances the weight-reducing effects of leptin and confers resistance to diet-induced obesity [50]

Eur J Pharmacol

Animal studies show a more pronounced impact, where AOD9604 increased lipolysis and prevented fat accumulation, but these results dont fully translate to humans (example)

It is a coenzyme your cells already make from vitamin B3, and it is central to two things: shuttling electrons through energy metabolism, and serving as a required cofactor for sirtuins, PARPs, and CD38

Parasutterella colonization has been shown to alter tryptophan, tyrosine, and xanthine metabolism in mouse cecal samples 61
