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Some scholars also believe that the plateau environment negatively affects the quality of male sperm, and these effects increase as the altitude increases [50]

As expected for the intended effect of ADT, metabolite set enrichment analysis (MSEA) of the significantly different metabolites revealed steroid hormone biosynthesis pathways, including androstenedione metabolism as well as androgen and estrogen metabolism, to be overrepresented by metabolites that were significantly different between +ADT and ADT groups (Figure 1E)

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Bordoni L, Sawicka AK, Szarmach A, Winklewski PJ, Olek RA, Gabbianelli R

SARS-CoV-2 NEUROINVASION IN COVID-19: OVERVIEW OF ENTRY MECHANISMS SARS-CoV-2 directly affects the nervous system [29]