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MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

Finally, although there are no data on mycobiota alterations in LC, a study has found increased levels of fungal translocation from the gut and/or the lung epithelia, determined by -glucan, a fungal cell wall polysaccharide, in the plasma of individuals of LC, suggesting the important role of fungal translocation in chronic immune activation due to gut barrier permeability [295]

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