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In: Pombo M, Rosenfeld RG, editors

In addition to its direct antitumor effects, daratumumab exerts an indirect immunomodulatory role by eliminating CD38 + immunosuppressive cell types (Treg, Breg and myeloid-derived suppressor cells) in the tumor microenvironment (TME), thereby promoting T-cell proliferation and effector functions [44]

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Zorrilla-Vaca A, Rice D, Brown JK, Antonoff M, Sepesi B, Hofstetter W, Swisher S, Walsh G, Vaporciyan A, Mehran R, Hagberg C, Mena GE

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