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Description
On the other hand, in the amyloidogenic pathway, APP at the N-terminal part of the A domain is cleaved by -site APP cleaving enzyme 1 (formerly known as -secretase) (BACE-1), resulting in release of extracellular soluble fragments of sAPP and a membrane bound C99 or -CTF [129, 130]
A previous study identified a set of naturally occurring human regulatory T cell epitopes (Tregitopes), present in the Fc and Fab domains of IgG, that induce tolerance when co-administered with other proteins (119)
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OMM, Outer mitochondrial membrane
