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Joints requiring a large surface area of cartilage restoration are challenging for a number of reasons, including mechanical demands, graft fixation, and the large number of cells required for transplantation (in cell based therapies)

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GIP receptor activation does not produce the nausea and gastrointestinal distress that limits GLP-1 receptor dose escalation

[DOI] [PubMed] [Google Scholar] 58.Trejo CG, Lozano D, Manzano M, Doadrio JC, Salinas AJ, Dapia S, et al