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Abnormalities of the heme oxygenase/carbon monoxide system have been critically linked to vascular contractility, increased oxidative stress, and imbalanced cellular apoptosis and proliferation in the vascular wall (214)

In addition to proper identification, the amount present was of paramount importance for melatonin when considering whether to include samples in this study or not

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Consequently, it is necessary to measure all relevant compartments to assess whether a molecule such as ERG, whose distribution is strictly transporter-mediated, is protective against a particular disease/effect or otherwise in a particular place or case