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Human data are limited and mixed: Clinical studies have largely assessed safety and metabolism, while weight-related outcomes were modest and inconsistent
In the past few years, understanding of the mechanisms involved in regulating feeding behavior and energy expenditure has evolved considerably, and targeting these mechanisms for drug development has garnered greater attention as well

This varies a lot

Endocrinology & Metabolism, 140(12), 5616-5621

Fu T, Xu Z, Liu L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, et al