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5.2 Underlying mechanism of DKD-related cognitive dysfunction Renal impairment induced by DKD is closely linked to cognitive dysfunction, which can be explained by various pathogenic mechanisms, including metabolic, vascular, and sociodemographic factors

Once reconstituted with bacteriostatic water, the solution is generally stored refrigerated (2-8C) and used within the window supported by internal stability testing

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Moreover, it caused nuclear p53 exclusion and induced apoptosis selectively in senescent Leydig cells by disrupting the FOXO4-p53 interaction, which may be a critical mechanism underlying its therapeutic effect