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Betaine, an antioxidant, mitigates these effects, reducing OS and restoring kidney structure [233]

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127 SFAs, such as palmitic acid, can increase the production of ceramide and NO, leading to impaired insulin synthesis, and the apoptosis of cells through inflammation, ERS, and oxidative stress, which can be blocked by unsaturated fatty acids

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The use of A42H13L (TABLE 1), in which one of the adjacent His residues was replaced by Leu, a substitution that would preclude any bidentate Cu 2+ ligand binding, led to results consistent with the notion that bidentate Cu 2+ ligand binding of these His residues was not essential for the oxidative damage and cellular toxicity of the native peptide (115)

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Note that, although oxidative stress is accepted as a key modulator of the biological processes in neurodegenerative diseases [141], therapeutic interventions must also take into account the useful endogenous mechanisms regulated by ROS [142]

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