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2013 Jul;169 Suppl 2(0 2):1-8

2.3 Genetic susceptibility: shared genetic architecture EDC exhibits significant genetic susceptibility, with its comorbidity risk potentially influenced by shared genetic variants

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According to dynamic simulation, the T17S, N68D, and I77V mutations change the secondary structure pattern, resulting in more helices and sheets that consequently improve the stability of the protease [15]

doi: 10.1016/j.bbr.2020.113094 142 YangYWangBZhongZChenHDingWHoiMPM
