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phosphatidylinositol (PI) elevates in M2, while phosphatidylethanolamine (PE), Cholesterol, TAG, and Ceramide (Cer) elevate in M1 (Fig

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After years of research, it has now been shown that a deficiency of the vitamin leads to an increase in myelin-damaging cytokines and a decrease in myelin-promoting cytokines (34)

This is consistent with the hypothesis that the cell has an over-capacity to chelate metal [208]