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Metabolic reprogramming is regarded as one of the emerging hallmarks of cancer (9)

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A Systematic Review of the Incidence, Prevalence, Costs, and Activity and Work Limitations of Amputation, Osteoarthritis, Rheumatoid Arthritis, Back Pain, Multiple Sclerosis, Spinal Cord Injury, Stroke, and Traumatic Brain Injury in the United States: A 2019 Update

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Bromodomain-containing protein 4 (BRD4), an epigenetic regulator that specifically recognizes and binds to acetylated histones through its bromodomain and then acts as a scaffold protein to recruit the transcription elongation factor b (P-TEFb) complex to facilitate the transcription of acetylated chromatin regions, plays a crucial role in the onset and progression of various diseases, including thyroid cancer [59,60,61]