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[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency

Chronic DNA damage burns through NAD+ over time, which can compete with energy-production needs

In contrast, fewer adults said they would be very likely to participate in the nutrition (36%) and physical exercise (26%) components of a structured program, suggesting many adults age 40 and older still characterize brain health as a cognitive activity, rather than something that is addressed holistically through attention to physical health as well

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