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Apart from inflammatory cytokine production, iron excess has been shown to exacerbate atherosclerosis development by enhancing glycolytic metabolism, thereby supporting the M1 phenotype (98)
Despite being widely considered as an important diabetic mouse model, db/db mice have relatively low-tolerance to rifampicin treatment as evident from the observed mortality when M
Similarly, dietary supplementation with 1% cholesterol reduces hepatic CYP51A1 mRNA and protein levels in Sprague-Dawley rats
A., Sheppard, M
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