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These modifications are also believed to assist at least 90% of the peptide to bind covalently to blood albumin, with trace amounts potentially binding to fibrinogen and immunoglobulin G (IgG)

Conclusions In addition to the conventional mechanism of desensitization, which occurs on the plasma membrane and in the cytosol, this study provides a new insight that another desensitization pathway in which nuclear trafficking plays a critical role is operating