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The evidence of the necessity for NADP(H) in proline biosynthesis can be demonstrated by the fact that loss of NADK2 activity impairs proline synthesis
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Similarly, infection of alveolar pneumocytes cells by SARS-CoV-2 virus triggers the initiation of systemic inflammation and elevated immunoreactivity that potentiate T-cell and macrophage activation infiltrating infected myocardial tissues, leading to cardiovascular damage and myocarditis
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