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Intervention with disulfiram, an FDA-approved drug that inhibits GSDMD-N pore formation 25 , partially attenuated noise-induced hearing dysfunction (Supplementary Fig

Accordingly, SFN significantly inhibited the activation of untransformed human T-cells derived from healthy donors or RA patients, and downregulated the expression of the transcription factor RORt, and the T H 17-related cytokines IL-17A, IL-17F, and IL-22, which play a major role within the pathophysiology of many chronic inflammatory/autoimmune diseases

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