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High-fat diet-mediated proximal tubule injury can reduce intracellular lipid accumulation by inhibiting the disruption of mitochondrial function, improving renal function, and preventing RF [86]

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This is particularly problematic for oral ingestion because the gastrointestinal tract is unfavorable for curcumins stability, as will be discussed below

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Molecules 19(9):1320013211 Zanzabil KZ, Hossain MS, Hasan MK (2023) Diabetes mellitus management: an extensive review of 37 medicinal plants

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