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[31], the mean duration between the initiation of metformin treatment and the onset of vitamin B12 deficiency was 5.3 years

Common causes include dietary deficiency (eg, vegan or vegetarian diet, low intake of meat or dairy products), use of proton-pump inhibitors or H2 blockers, and poor B12 absorption due to age-related changes in the stomach (eg, atrophic gastritis)

[DOI] [PubMed] [Google Scholar] 12.Dallongeville J, Fruchart JC, Auwerx J
