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Cell 162: 540551 Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, Schenkein DP, Hezel AF, Ancukiewicz M, Liebman HM, Kwak EL, Clark JW, Ryan DP, Deshpande V, DiasSantagata D, Ellisen LW, Zhu AX, Iafrate AJ (2012) Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broadbased tumor genotyping

Epithelial cells give up their distinctive polarity and cell-to-cell interactions during EMT in favor of a more mobile, mesenchymal phenotype

However, because many people live undiagnosed for years with autoimmune conditions like celiac disease or Hashimoto's (and often both), it can often show up around the same time
