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Magnesium Why it matters: Magnesium is a cofactor in more than 300 reactions, including those involved in energy production, the synthesis of proteins and antioxidants, and blood glucose control

Subsequent studies revealed heightened sensitivity of MM cell lines to ferroptosis, with combined bortezomib and iron chelation exhibiting superior efficacy in suppressing disease progression compared to monotherapy, these findings collectively underscore the critical role of ferroptosis in MM pathogenesis (Figure 3)

Although the dismutation of superoxide by SOD2 is a predominant source of H 2 O 2 , there are other reactions that directly generate H 2 O 2 in mitochondria

Research indicates that it can alleviate kidney tissue lesions and mitochondrial damage in mice, reducing inflammatory responses (180)