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Lipotropic agents, like choline, inositol, and methionine, help the body break down and metabolize fat

Inadequate absorption or utilisation of Vitamin B12 because of age, gastric abnormalities such as Coeliac disease, inflammation of the stomach or intestines, after stomach and bowel surgery, and inflammatory bowel diseases (Crohns disease)

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Administration in combination with tetracyclines, because of the interaction of iron with tetracyclines

Effect size and physiological context