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Estrogens exert antidepressant activity via multiple mechanisms: the regulation of 5-HT synthesis, metabolism and function, and neurotrophic activity to promote neuroplasticity and neurogenesis [95]

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[172] utilized B16F10 murine melanoma cells and reported similar observations

Trial populations differ from real-world MASH patients, who often have diabetes, advanced fibrosis, and comorbidities that modify both efficacy and risk

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