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3.3 Systemic fate and excretion Once produced, most TMAO enters the systemic circulation, with a portion being taken up by extrahepatic tissues

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The approach combined high-dose enzyme replacement therapy with sebelipase alfa, prophylactic rituximab to prevent anti-drug antibody development, and early hematopoietic stem cell transplantation (HSCT)

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Upon heat shock (1-20 min at 35 C), HSF-1 tagged GFP (HSF-1::GFP) forms foci in the hypodermal nuclei, but the HSF-1::GFP foci are difficult to score in the intestinal nuclei (Chiang et al

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May 2016;36(3):461-493

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