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Potential mechanisms of action are summarized as follows

The story of Rett syndrome: From clinic to neurobiology

Kidney or liver disease As the kidneys and liver help create and use L-carnitine, disease in these organs or organ failure Doctors may recommend L-carnitine supplementation in these cases to support the function of the kidneys and liver and prevent deficiency

In the case of renal impairment, urinary elimination of carnitine increasing, endogenous synthesis decreasing, and poor nutrition as a result of disease-induced anorexia can result in carnitine deficiency

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Zhang AQ, Mitchell SC, Smith RL