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Some practitioners employ intermediate dose increases, such as escalating by 0.25 mg increments rather than doubling doses, to improve tolerance in sensitive patients

High dose intravenous colistin methanesulfonate therapy is associated with high rates of nephrotoxicity

Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, et al
The Urology Care Foundation agrees, saying that although supplements are popular and often cheaper than prescription drugs, they are not guaranteed to be safe or effective
