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doi: 10.1016/S0304-3940(03)00185-X

Controversy over the role of DHODH in ferroptosis regulation Although ferroptosis was initially thought to be primarily executed at the plasma membrane, a pivotal study by Boyi Guans group highlighted mitochondria as a potential site of critical lipid peroxidation, particularly under conditions of GPX4 inactivation or in GPX4-low cell lines 23

Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies

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These studies establish a role for GPX4 in blocking CASP-dependent and -independent apoptosis, which is associated with tissue development