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Oswald MCW, Garnham N, Sweeney ST, Landgraf M (2018) Regulation of neuronal development and function by ROS

In addition to its role in glycolysis, studies have shown that the PKFM encoded isoform of PFK-1 can be localized to the nucleus where it functions as a histone kinase

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Recruitment of this complex is associated with increased expression of CCL3 ( Therefore, the severe form of COVID-19 induces hypomethylation of a CpG locus in the regulatory region of CCL3 , which is coherent with its upregulation

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