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Metabolic instruction of immunity

doi: 10.1038/nrmicro2097 342 VirjiM.AlexandrescuC.FergusonD

Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans

98 Furthermore, esculentoside A, with satisfactory antioxidant activities, could enhance the Nrf2-mediated survival mechanisms through the AMP-activated protein kinase (AMPK)/Akt/glycogen synthase kinase-3 beta (GSK3) pathway, thus effectively alleviating APAP-induced liver damage

Collectively, this study identifies the ACAT1/DLD axis as a metabolism-centered effector of TGFs tumor-suppressive function and proposes a combinatorial strategy to improve therapeutic outcomes in GC