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A limitation of this study was the relatively low tumor uptake values seen compared to the uptake values observed in the study conducted by Mateusiak et al., describing the generation and validation of the uPAR15 sdAb ( 99m Tc]Tc(CO) 3 , and uPAR15-GEM-[ 99m Tc]Tc(CO) 3 -IRDye800CW in the same tumor model would be required to further assess the impact of the GEM-handle on the in vivo targeting of sdAb-based tracers

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[DOI] [PMC free article] [PubMed] [Google Scholar] Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al

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Critical evaluation of the illumina methylationepic BeadChip microarray for whole-genome DNA methylation profiling
