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Microglial activation leads to both beneficial and harmful effects [1, 2]

However, somewhat paradoxically, recent evidence suggests that Masters athletes who have engaged in lifelong competitive exercise may actually have greater risk of atherosclerotic plaque formation compared with sedentary controls (Reference Merghani, Maestrini and Rosmini122,Reference Schwartz, Kraus and Schwartz123)

10.3390/nu8020099 Nutrients 168 WortmannM.SchneiderM.PircherJ.HellfritschJ.AichlerM.VegiN.et al (2013)

Moreover, the dominance of FOX P3, GATA binding protein 3 (GATA3), and IRF4 PU.1 in the lamina propia of UC patients promotes inflammation

Once they are water-soluble, the "exit doors" of the body open up