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Description
tasiRNAs are a unique group of small RNAs in plants that mediate gene silencing
It is converted into a physiological form once metabolized
For example, TAMs consistently maintain a pro-tumoral M2-like state, which may involve irreversible epigenetic reprogramming or metabolic locking mechanisms, such as exosomal lncRNA HAGLROS promoting M2 polarization though its regulatory network remains unknown
The induction of the PPAR target gene UCP2 might be associated with a protective role, as confirmed by the sensitivity of Ucp2 -/- mice to APAP-induced toxicity [16]
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