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While both forms can be used as a supplement, ALCAR is often preferred due to its ability to cross the blood-brain barrier allowing it to interact with nerves in the brain, and also donate its acetyl molecule, a key step in neurotransmitter formation, required for healthy brain activity

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The authors suggest that their studies provide insights into A42 and brain insulin resistance as a significant contributing component of the pathophysiology of AD (180)

NAC's ability to replenish glutathione and reduce oxidative stress, along with ALC's support for mitochondrial function and neurotransmitter synthesis, make them valuable in treating a wide range of conditions, including neuropsychiatric disorders and complications related to COVID-19

In addition, the inverse-variance method was implemented to compute the weighted mean differences with 95% confidence intervals (CIs) for the remaining outcomes (serum levels of estrogen, progesterone, and testosterone