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Matamales et al mapped a DA-dependent transcriptional activation marker in spiny projection neurons expressing D1 or D2 receptors in mice.54 This dynamic transmodulation is essential for updating goal-directed learning and reshaping volitional action

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Whiteford HA, Ferrari AJ, Degenhardt L, Feigin V, Vos T

Funding Statement The authors have no support or funding to report

This multi-route evaluation demonstrated that AOD-9604s favorable safety profile was not dependent on a specific delivery method, though bioavailability differed between routes